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Health experts stress that the best outcomes happen when medication is paired with long-term lifestyle changes
Weight loss trajectory was still accelerating Phase 1 (oral): 10.4-13.1% weight loss at 12 weeks depending on dosing regimen vs 1.2% placebo Phase 2 (T2D): SC amycretin showed up to 14.5% weight loss and HbA1c reductions up to 1.8% at 36 weeks
Furthermore, it limits the food intake because of inhibiting the appetite
Case reports and small case series have described NAION occurring in patients treated with semaglutide
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